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NEUROLOGY 2006;66:737-739
Neuropsychological deficits in long-term frequent cannabis users
Lambros Messinis, PhD, Anthoula Kyprianidou, BSc, Sonia Malefaki, PhD and Panagiotis Papathanasopoulos, MD, PhD

From the Department of Neurology (L.M., P.P.), University Hospital Patras, Patras, Greece; Department of Speech and Language Therapy (A.K.), Higher Technological Institute of Patras, Patras, Greece; and Department of Statistics and Insurance Science (S.M.), University of Piraeus, Piraeus, Greece.

Address correspondence and reprint requests to Dr. Lambros Messinis, Rixinoros 6, Patras 26442, Greece; e-mail: lambros@hellasnet.gr

Abstract:

The authors examined neuropsychological functioning in 20 long-term (LT), 20 shorter term (ST) heavy frequent cannabis users, and 24 controls after abstinence for ≥24 hours prior to testing. LT users performed significantly worse on verbal memory and psychomotor speed. LT and ST users had a higher proportion of deficits on verbal fluency, verbal memory, attention, and psychomotor speed. Specific cognitive domains appear to deteriorate with increasing years of heavy frequent cannabis use.